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Hum Mol Genet 23(4):980991 Herman DS, Lam L, Taylor MR, Wang L, Teekakirikul P, Christodoulou D, Conner L, DePalma SR, McDonough B, Sparks E, Teodorescu DL, Cirino AL, Banner NR, Pennell DJ, Graw S, Merlo M, Di Lenarda A, Sinagra G, Bos JM, Ackerman MJ, Mitchell RN, Murry CE, Lakdawala NK, Ho CY, Barton PJ, Cook SA, Mestroni L, Seidman JG, Seidman CE (2012) Truncations of titin causing dilated cardiomyopathy

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It can be chronic (repeated, tiny trauma) or acute (after a single large trauma)

Adimoolam says, meaning it has multiple causes

Some of leptin's effects have been shown to result from its effect on melanocortin levels [4]