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Research in earlier phases or small trials include evaluation of GLP-1s for cystic fibrosis-related diabetes, polycystic ovarian syndrome (PCOS), chronic obstructive pulmonary disease (COPD), Prader-Willi syndrome (PWS), asthma, substance or alcohol use disorder and as add-on to insulin for type 1 diabetes
Keep Your GLP-1 Medication at the Right Temperature Most GLP-1 medications should be kept refrigerated until use, though many are stable at room temperature for a limited time
Importantly, GIP receptor sensitivity is impaired in prolonged hyperglycemic states due to receptor downregulation but can be restored upon achieving euglycemia through complementary GLP-1 action [38,39]
Safety profiles were largely favorable, though gastrointestinal side effects and discontinuation rates varied by agent and dose
doi:10.1056/NEJMoa2500969 2
