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Studies have demonstrated that Hinge binds to HGF with high affinity blocking its dimerization and acting as a potent inhibitor of HGF-dependent cellular activities including MDCK D-Nle-X-Ile-NH-(CH 2 )s CONH 2 analogs modify HGF/Met mediated cell scattering in MDCK cells HGF/Met signaling is the hallmark effect of HGF/Met signaling

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Electron microscopy L3-L5 DRG tissue was collected from mice following perfusion with 4% paraformaldehyde (PFA) and 4% glutaraldehyde

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This enabled us to assess whether the structural differences and conformational dynamics observed in the Cagri and rAmy bound AMYR structures alter the nature of Gs protein interaction (Supplementary Fig