Neither approach is better. What matters is finding the lowest dose that continues helping you reach your goals while minimizing side effects and supporting long-term health
When insulin levels are better managed, the body is less likely to store fat
J Biol Chem 280:3241332418 Wang H, Brun T, Kataoka K, Sharma AJ, Wollheim CB (2007) MAFA controls genes implicated in insulin biosynthesis and secretion
But once tirzepatide was withdrawn, the degree of weight regain strongly predicted the reversal of those benefits
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