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After 12 weeks of taking phentermine, the majority of patients lose at least 5% of their body weight, and about 25% lose at least 10% of their body weight

This precursor approach is largely self-regulating

Hydration recommendations form the cornerstone of prevention: Fluid intake targets : Patients should aim for sufficient fluid intake to produce at least 2.5 liters of urine daily, in accordance with American Urological Association guidelines

-melanocyte-stimulating hormone (-MSH)-MC1R signaling pathway -MSH is a precursor polypeptide derived from pro-opiomelanocortin that can modulate pigmentation through paracrine action, whilst MC1R is a member of the G-protein-coupled receptor family (20)

N Engl J Med 384 , 9891002 (2021)