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Long-term administration of berberine increases the expression of IL-1 and inducible nitric oxide synthase (iNOS) in Alzheimers disease mice hippocampus, and ameliorate memory impairment (Zhu and Qian, 2006)

Deletion of NOX by genetic approaches or using NOX inhibitors, is protective against neurotoxicity in ALS disease models (Sorce et al., 2017

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