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Our study suggests that semaglutide may have bone protective effects despite its effect on weight loss, explained Kim

This can cause significant uncomfortable side effects like nausea, bloating, and constipation

Most patients who stop GLP-1 treatment regain a significant portion of the weight they lost, which is why discontinuation is generally not recommended unless side effects or other clinical concerns warrant it

J Biol Chem 279: 2228422293 GrabowskaD,ChelstowskaA (2003) The ALD6 gene product is indispensable for providing NADPH in yeast cells lacking glucose6phosphate dehydrogenase activity