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Probiotics, prebiotics, and synbiotics: gut and beyond

Indirect oxidative effects of hyperhomocysteinemia may include generation of superoxide from uncoupled endothelial nitric oxide synthase (eNOS), xanthine oxidase, or NAD(P)H oxidase, downregulation of antioxidant enzymes, and depletion of intracellular glutathione

Given the complexity of aging, a multi-faceted approach that includes both antioxidant support (like NAC) and metabolic enhancement (via NAD precursors) might be most beneficial