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The medication is also not recommended for patients with severe gastrointestinal disease, including severe gastroparesis

Autonomic Nervous System (ANS) Dysfunction The ANS, composed of sympathetic and parasympathetic branches, plays a crucial role in modulating gastrointestinal motility and secretion, with the vagus nerve being particularly important for regulating lower esophageal sphincter (LES) tone, gastric emptying, and salivary secretion

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A summary of the multiple mechanisms through which GLP-1RAs have been hypothesized to beneficially affect NAFLD based on animal studies are depicted in Fig