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Biol Pharm Bull (2015) 38(5):694702

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Chantler S, Griffiths A, Matu J, Davison G, Holliday A, Jones B

The variant that causes chronic hemolysis is uncommon because it is related to sporadic gene mutation rather than the more common inherited gene mutation

They have come into the limelight after a large double-blinded study published in NEJM, showed an average 14.9% decrease in weight in obese patients given semaglutide on top of lifestyle modifications, compared to 2.4% in the control arm (see research summary at end)