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The differing toxicities of ionizable organic compounds at different pH values can be attributed to the distinct permeabilities of the existing species (i.e., neutral and ionized forms) because neutral species can permeate biomembranes and become trapped in cells faster than the corresponding charged species, resulting in distinct differences in the internal concentrations

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As a result, N-Acetyl Semax Amidate has been reported to last 30 minutes longer than Semax before being degraded in blood plasma, while also expressing increased stability in brain tissue, indicating potentially extended nootropic effects after application [6, 8]