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131,132,133 MSCs have been shown to directly degrade Keap1 and activate Nrf2 activity, which increases the levels of HO-1 and NQO-1, inhibits the infiltration of colonic inflammatory cells and the expression of proinflammatory cytokines, and maintains the permeability of the mucosal barrier of colon epithelial cells

Some individuals may experience more substantial early weight loss, particularly if they make significant concurrent lifestyle modifications or have higher baseline body weight

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