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Concomitant use of hydrocodone bitartrate and acetaminophen tablets with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could decrease hydrocodone plasma concentrations, decrease opioid efficacy or, possibly, lead to a withdrawal syndrome in a patient who had developed physical dependence to hydrocodone

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Ans: No

10.1007/978-1-4614-1025-6 28 HeP.ZhangX.WuW.LiuG.LiuS.WangC.et al (2022)