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The limitations stem from the retrospective nature of the study

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In addition, replenishment of B-complex vitamins, such as B-12, B-6 and folic acid, is suggested to prevent homocysteine accumulation and to enhance the availability of methyl groups (225, 228, 256) Figure 2 For the treatment of SIBO outbreaks, as a consequence of immunosuppression and mucosal inflammation, the use of antibiotic agents is considered relevant (258)