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Such studies are inherently susceptible to confounding by socioeconomic status, access to healthcare, reimbursement policies, and patient adherence, all of which may significantly impact treatment continuation and metabolic outcomes

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In Eli Lillys Phase 3 TRIUMPH-4 trial (December 2025), participants at the 12mg dose lost an average of 28.7% of body weight at 68 weeks up to 71.2 lbs per person

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Statements Author contributions WW: Data curation, Writing original draft, Writing review & editing, Formal analysis, Investigation, Visualization

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