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The relationship between the gut microbiota and the effects of cannabis has been a subject of growing research interest, with potential implications for individual variations in cannabinoid metabolism, immune response, and gut barrier integrity

The side-chains of the acidic amino acids Asp and Glu have pK values of 3.9 and 4.1, respectively, whereas those of the basic amino acids Arg and Lys, have pK values of 12.5 and 10.8, respectively