8 Patients were given a solution with 200 mg glutathione or placebo
Results: Administration of high dose MTX (5 mg/kg) today 4 produced a significant decrease in hepatic glutathione (GSH) levels and a significant increase in ALT and AST liver enzymes, hepatic malondialdehyde (MDA), tumor suppressor protein (p53), interleukin 6, interleukin 1 levels compared to the control group
The work also gave them a chance to see how patients fared outside the idealized setting of a clinical trial, which typically provides free medication, regular check-ups and other types of support
Their high cost, combined with the large number of people who might benefit and the potential for longterm use, has intensified employers concerns about the financial burden of covering GLP1 medications for weight management
Reports from real patients show that side effects might happen more or less because doses can differ