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Oxidative stress and 4-hydroxy-2-nonenal (4-HNE): implications in the pathogenesis and treatment of aging-related diseases

1):3943 Chiechio S, Copani A, Zammataro M, Battaglia G, Gereau RW 4th, Nicoletti F (2010) Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain

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Treatment usually starts at 0.25 mg once weekly for 4 weeks, then increases to 0.5 mg

If you have type 2 diabetes or non-diabetic hyperglycaemia (prediabetes) and are on combination therapy, an inadvertently shortened dosing interval might increase the risk of hypoglycaemia