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In old rats with OVX-induced osteoporosis, exendin-4 decreased the concentration of C-terminal cross-linked telopeptides of type I collagen (CTX-1) and the urinary deoxypyridinoline (DPD)/creatinine ratio ( GLP-1 Decreases Bone Resorption through a Calcitonin-Dependent Pathway Glucagon-like peptide-1 receptor is expressed in thyroid C cells and can promote the secretion of calcitonin through a cAMP-mediated pathway in these cells ( / mice had decreased mRNA levels of calcitonin