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It also significantly reduced inflammatory markers TNF-alpha and destructive enzymes MMP-2/MMP-9

Freezing stress can cause phase separation, aggregation, and loss of bioactivity

Furthermore, the accumulation of AGEs not only alters the structure and function of the extracellular matrix but also, through interaction with their receptor (RAGE), activates multiple signaling pathways that inhibit the osteogenic capacity of BMSCs (25)

Wegovy stands out as a stronger, more reliable choice due to its FDA approval and consistent results demonstrated through clinical trials

To date, no studies have systematically assessed the relationship between endothelial dysfunction and glucocorticoid dose, type, or treatment duration