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Although it shows a protective effect against hypertension and kidney damage induced by RUPP rats when administered in late gestation, it exacerbates the preeclampsia-like phenotype when given in early gestation, predisposing to a smaller placenta and increasing proteinuria

Cag acts centrally on amylin receptors in the hypothalamus and brainstem to reduce appetite, lower food intake, suppress post-meal glucagon release, slow gastric emptying, and support improved blood glucose regulation

Some common GLP-1 medications include: Semaglutide (brand names include Ozempic, Wegovy) Liraglutide (brand names include Saxenda, Victoza) In clinical trials, these medications have shown an average weight reduction of around 10-15% of body weight, depending on the dose and duration

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