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By week 23, subtle changes often become visible: clothes fit differently, water retention may decrease, and energy levels sometimes shift

Davies M et al (2021) Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial

Both require similar gradual dose escalation schedules to minimize side effects

Albert, J

The supplement industry benefits from a regulatory gap where manufacturers can market products based on 'structure-function' claims rather than disease claims, requiring lower evidence thresholds