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Notably, this benefit occurred without greater shortterm weight loss or greater reductions in epicardial fat compared to riskfactor modification alone, suggesting the therapy may work through more complex biological pathways

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Renal function requires particular attention, as GLP-1 receptor agonists that are primarily renally eliminated, such as lixisenatide and exenatide, are contraindicated in severe renal disease, which is more prevalent in this group

J.2000Formation of hydroxyl radicals in the human lens is related to the severity of nuclear cataract.Exp Eye Res.708188

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