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Clinical Considerations Disease-associated maternal and/or embryofetal risk Poorly controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, preeclampsia, spontaneous abortions, preterm delivery and delivery complications

MATERIALS AND METHODS Animals and Surgery Male Sprague-Dawley rats (Taconic derived) weighing 390-450 g were maintained with free access to water and food (Harland Tekland F6 rodent diet, Madison, WI) except the night prior to surgery when food was removed

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doi:10.1186/s13195-021-00850-3 24

To understand the role that glutathione plays in the body and how MTHFR impacts it, its important to understand methylation