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If the acetaminophen concentration cannot be obtained (or is unavailable or uninterpretable) within the 8- hour time interval after acetaminophen ingestion or there is clinical evidence of acetaminophen toxicity: Administer a loading dose of ACETADOTE immediately and continue treatment for a total of three doses over 21 hours

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To determine which enzyme was responsible for the PQ cleavage pattern she observed, her team cultured bacterial colonies from saliva samples and tested their activity toward gluten-derived substrates, eventually identifying a subtilisin enzyme in Rothia mucilaginosa and Rothia aeria bacteria as the snipper (2,3)

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