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79 AT 2 receptor-mediated vasodilation has been shown in small resistance arteries of the mesenteric, uterine, adrenal, coronary and peripheral circulations in a wide variety of animal models and, in human beings, in large capacitance vessels such as the aorta and in the fetal circulation

This inflammation is closely linked to adipose tissue dysfunction and systemic insulin resistance, contributing to the exacerbation of HS symptoms [5,6]