semaglutide in heart failure Impact of on health outcomes and mood obese patients: a retrospective analysis | Clinical Research in Cardiology Semaglutide may reduce heart events

When semaglutide binds its receptor on the outside of a neuron, the receptor signals the inside of the cell partly by making cAMP

10.1186/1741-7015-11-117 BMC Med

with sulfonylureas) - Injection site nodules (Bydureon)AMIGO Trials DURATION TrialsLixisenatide (Adlyxin)- Mild A1C reduction (~0.7%) - Less weight loss - Once-daily injection- Nausea - Vomiting - HeadacheELIXA TrialDulaglutide (Trulicity)- A1C reduction ~1.3% - Weight loss ~24% - Once-weekly injection - Cardiovascular benefit- GI symptoms - Injection site irritation - Pancreatitis risk (rare)REWIND Trial

Effects on milk production and weight loss medication The exact effects on milk production in the body when weight loss medications are taken during breastfeeding havent yet been determined, other than that they may pass into breast milk

(PubMed) McNulty H, Strain JJ, Hughes CF, Pentieva K, Ward M