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Tozuleristide is currently in clinical development focused on pediatric central nervous system tumors

Physical activity, dietary changes, and other microbiota-targeted intervention strategies discussed in this review are extremely beneficial in CKD management as they offer a non-invasive approach to the reduction of uremic toxins, enhancement of the intestinal barrier integrity and that of the BBB, lowering inflammation and oxidative stress, SCFAs generation, modulation of neurotransmitter levels, and immune responses that ultimately slow kidney function decline, decreasing the occurrence of associated complications, and greatly improving the quality of lives of affected individuals

Acknowledgments We deeply thank Aurlie Derom and Chrissy van de Voorde for their support in recruiting participants and during data collection

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