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Other clinically important adverse reactions occurring in 10% of the HALAVEN-treated patients were nausea (41%), vomiting (19%), diarrhea (17%), asthenia/fatigue (62%), peripheral edema (12%), decreased appetite (19%), arthralgia/myalgia (16%), back pain (16%), and cough (18%) 1 The median duration of exposure was 2.3 months (range: 21 days to 26 months) for patients receiving HALAVEN 1 a Each test incidence is based on the number of patients who had both baseline and at least 1 on-study measurement and at least 1 grade increase from baseline
726 Consistent with clinical observations, unilateral, transient middle cerebral artery occlusion/reperfusion (MCAO/R) caused a significant increase in free iron levels, or ferritin levels, in the brains of mice
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