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In patients with type 1 diabetes, intensive glycemic control with an A1C goal of approximately 7% reduces the risk of symptomatic neuropathy by up to 60%

11, 29 Although it is unclear whether the accumulation of iron in the brain is primary or secondary to the development of neurodegenerative disorders, 30 one animal study has shown that unilateral injection of FeCl 3 into the substantia nigra of adult rats results in a 95% decrease of striatal dopamine, which impaired dopamine-related behavioral responses

A larger meta-analysis encompassing over 77,000 participants similarly reported a reduced overall risk of respiratory diseases with GLP-1 receptor agonist treatment, but pulmonary fibrosis was not analysed as a discrete outcome, and no fibrotic endpoints were prospectively assessed [64]

doi: 10.1111/jcpt.13225 60 TangYZhangLZengYWangXZhangM