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In the gastric tumor microenvironment, inflammatory cues activate NF-B and HIF-1, which cooperatively bind the MDR1 promoter and drive P-gp overexpression, thereby conferring resistance to paclitaxel and doxorubicin

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Sequence alignment and percentage of similarities were derived using ClustalW v2.1 19 available on the website of EMBL

HDAC6 inhibitor Ricoliostat: HDAC6 inhibitors can promote the degradation of protein aggregates or protect neurons from oxidative stress, hence can be used as possible drugs for treating peripheral neuropathy

These components, along with others, have the potential to alleviate the negative effects of salt stress