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Impairment of proinsulin conversion may be another mechanism for TCF7L2 associated diminished GLP-1 efficacy [568]

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However, recent research has revealed a potentially groundbreaking application: using GLP-1 receptor agonists to curb addiction to substances such as alcohol, nicotine, and opioids

Potentially more serious (but much less common) side effects can include pancreatitis, gallbladder inflammation, dehydration leading to kidney injury, low blood sugar and allergic reaction