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2005 Sep;29(4):62551

In this model, iodine deficiency and Se deficiency exacerbate H2O2 accumulation, Se deficiency decreases cellular defense, promotes thyroid cell fibrosis, increases the inflammatory response following thyroid cell necrosis, and thiocyanate overload triggers follicular cell necrosis

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When NRF-2 is exposed to inflammation or oxidative stress (OS), it phosphorylates and translocates into the nucleus, giving rise to the transcription of proteins and antioxidant enzymes [7]