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Studies conducted with Caco-2 cells in a laboratory setting, utilizing inhibitors of transporter proteins and knockout methods, have pinpointed the main transporter proteins responsible for metformin as the organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), serotonin transporter (SERT), and high-affinity choline transporter (CHT) (Han et al., 2015)

Andrew Huberman: And he was the one that really defined this kind of inverted U-shaped function for the relationship between adrenaline and memory

doi: 10.1038/nature05485

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