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Fat oxidation is driven by caloric deficit, not methyl donors

Doctors consider being overweight or obese a serious medical condition associated with an array of life-threatening problems, including 13 types of cancer, heart disease, diabetes, and liver disease

At diagnosis, 22 40.5% of patients with acromegaly exhibit elevated fasting glucose concentrations and/or impaired glucose tolerance and 12 34.9% diabetes mellitus (3742)

Lowering GSH levels also triggers ferroptosis through deactivation of GPX4, leading to accumulation of lipid peroxides [87] In some cases, GSH depletion alone can induce therapeutic effects without relying on Fenton chemistry, which typically involves HO reacting with Fe 2 to form hydroxyl radicals (OH) that damage critical biomolecules such as DNA, proteins, and lipids

M., Gladyshev, V