semaglutide doesn't work for me Why Stopped Working: 5 Real Reasons & Fixes Why Compounded Semaglutide Isn't Working

When to Consider Alternatives Sometimes a different medication is the right answer: tirzepatide produces greater average weight loss

Metabolic adaptation : The body naturally adapts to weight loss by reducing metabolic rate, a phenomenon sometimes called "adaptive thermogenesis." This biological response is expected and can slow or plateau weight loss even when medication and lifestyle factors remain consistent

Last reviewed: June 18, 2026 Last updated: June 18, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

[4] Gastrointestinal side effects may be more noticeable when dosing is inconsistent

Is regular exercise an effective strategy for weight loss maintenance