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In the landmark SELECT trial in 2023, the scope of GLP-1RAs was expanded to assess cardiovascular risk in patients with preexisting cardiovascular disease who were overweight or obese without type 2 diabetes [48]

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A landmark 21-month study published in Clinical Journal of Sport Medicine found no adverse effects on kidney function, liver function, or other health markers in healthy individuals using creatine long-term

We encourage researchers to maintain vigilance, document all observations, and contribute to the growing body of knowledge

In a real-world VA clinic setting, veterans treated with GLP-1 receptor agonists for weight loss showed broad improvements across multiple health markers after one year, reinforcing that the benefits of these medications extend well beyond the scale