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May 24 2017;57(8):1749-1758

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It is doubtful whether studies presented so far, based mostly on subjective and state-dependent symptoms and signs of severe GD that have not been identified in the very early stages of GD, may suggest that these agents might have potential benefits in the treatment of the entire spectrum of GD

11, 29 Although it is unclear whether the accumulation of iron in the brain is primary or secondary to the development of neurodegenerative disorders, 30 one animal study has shown that unilateral injection of FeCl 3 into the substantia nigra of adult rats results in a 95% decrease of striatal dopamine, which impaired dopamine-related behavioral responses