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Genetic Predispositions in GLP-1 Pathways: Why Individual Response Varies Research indicates that variants in GLP-1 receptor genes (GLP1R rs6923761), GIPR signaling (GIPR rs1800437), appetite regulation (FTO rs9939609), and melanocortin pathways (MC4R rs17782313) may contribute to individual differences in response to GLP-1 therapy