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Further, future studies are needed to identify the mechanisms behind this differential weight loss response, the researchers wrote

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Activation of the GLP-1 receptor leads to the generation of cyclic adenosine monophosphate (cAMP), subsequent cellular depolarization, and insulin secretion from pancreatic beta cells in response to feeding [42], [43], [44]

Summary: Rybelsus does not directly cause increased urination as it works through GLP-1 receptors rather than affecting kidney function or urine production

Furthermore, liraglutide and semaglutide have both demonstrated anti-fibrotic effects and their use in preclinical models prevents NASH-driven HCC progression (Sanyal et al., 2025