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[66] Humans with mutations in UNC93B1 , the human ortholog of the same gene, were subsequently found to be susceptible to recurrent Herpes simplex virus (HSV) encephalitis, in which reactivation of latent virus occurs repeatedly in the trigeminal ganglion at the base of the midbrain, leading to cortical neuron death

Additionally, adrenaline, which induces cAMP elevation and triggers calcium release from the endoplasmic reticulum, stimulates higher magnitude of calcium oscillation in GCGR-KO cells, indicating increased calcium release from the endoplasmic reticulum

But related, sunburns induce a lot of DNA damage and use up your NAD+ reserve because it activates internal repair mechanisms and starts depleting NAD+ at a higher rate

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