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Early-phase clinical trial data, including results from a Phase 2 trial published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023), demonstrated substantial weight reduction in participants receiving retatrutide with some individuals losing more than 20% of their body weight over 48 weeks

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An emerging approach involves leveraging renowned natural compounds from herbal medicine, such as celastrol, which is celebrated in traditional Chinese medicine for its therapeutic potential in various conditions, including obesity