This results in a slower metabolism, reduced functional capacity, hair thinning, fatigue, and less improvement in metabolic markers like blood sugar control
Combined SGLT2i and GLP-1RA therapy addresses multiple risk domains through complementary mechanisms and may be most effective within a phenotype-guided framework
They mimic the action of endogenous GLP-1, activating the receptor thereby enhancing insulin secretion, inhibiting glucagon release and delaying gastric emptying
That said, stopping suddenly does mean your appetite and digestion will return to normal more quickly, which can feel quite noticeable if youve been on the medication for a while
By increasing the body's levels of GLP-1, Wegovy keeps food in the stomach for longer and sends signals to the brain that it's full helping regulate appetite and supporting significant weight loss