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These findings informed human PET studies using the HDAC tracer [11C] Martinostat, which confirmed elevated HDAC expression in the brains of chronic drinkers

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Melatonin suppresses E2 production from the pre-ovulatory follicle via MAPKs, suppresses aromatase activity, and decreases the level of ER in ovaries and the level of ER in uterine tissue [108]