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Now worldwide adult obesity has become a major public health issue in recent years, and alarming obese populations are growing day after day among adults

As a solution, we report that C-terminally cleaved albumin can be efficiently rescued from intracellular degradation by introducing amino acid substitutions that improve FcRn binding

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Specifically, activating MCRs centrally in APP/PS1 murine models possibly reduces amyloid plaque formation and decreases levels of both soluble and insoluble A in brain regions like the hippocampus and cortex