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We now understand that weight regulation is influenced by hormones that control hunger, fullness, and blood sugar not simply discipline

P t 38, 349351

The GLP-1 sequence is highly conserved among mammals and is released in its active form (7-36) in response to food intake

Each choice involves a cost in terms of effort, time, and money

This is the clinical rationale for its positioning as a next-step option for patients who have plateaued on approved agents, rather than a replacement for them