flow trial semaglutide results Kidney and Survival Benefits of in Diabetes With Chronic Kidney Disease: Cardiovascular Subgroup Analyses ADA 24: FLOW Trial: Kidney

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F.HouY.PalikarasK.AdriaanseB

Increased oxidative stress, inflammation and lipotoxicity associated with hyperglycaemia and insulin resistance potentially impair vascular endothelial function and increase endothelial permeability, leading to the penetration of glycated and oxidized low-density lipoprotein (LDL) cholesterol into the endothelium, i.e., initiation of atherosclerosis