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This work was also supported by the National Key Research and Development Program of China (2018YFA0507001, 2018YFA0507000, 2018YFA0508100), the National Natural Science Foundation of China grants 31770898 (G.S.), 31900895 (L.Y.) and 81872915 (M.-W.W.), the National Science and Technology Major Project Key New Drug Creation and Manufacturing Program of China (2018ZX09735-001) and China Postdoctoral Science Foundation (2017M622365)

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The nucleic acid molecule of claim 26, wherein said nucleotide sequence region has the nucleotide sequence of SEQ ID NO:20