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3 Prevention of DPN Several lifestyle interventions have been shown to be effective in preventing DPN [17] especially by targetting known risk factors for developing DPN (Table 2)

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The selected studies demonstrated that tirzepatide, a dual agonist of GIP (glucose- nsulting insulinotropic peptide) and GLP-1(glucagon-likepeptide-1)receptors,hasbeenextensively investigated for its therapeutic efficacy and safety profile