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In the study of Tagitinin C-induced ferroptosis in colorectal cancer cells, it was found that the mechanism of action of Tagitinin C might be related to the activation of the PERK-Nrf2-HO-1 signaling pathway induced by ER stress, leading to ferroptosis (84)

LSECs line the tiniest blood vessels in the liver and are studded with pores that allow them to act as a molecular sieve, filtering substances passing between the liver and the bloodstream

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